Endocrine Abstracts

Introduction: Treatment options for progressive metastatic unresectable medullary thyroid carcinoma (MTC) include tyrosine kinase inhibitors (TKIs) or somatostatin analogues (SSA), although the efficacy of the latter is debatable. In such cases, combined treatment of TKIs and SSAs has not previously been reported.Aim: To present a metastatic MTC case successfully treated with a combination of Vandetanib and Lanreotide Autogel.Case ...

Purpose: To present a rare case of diabetic ketoacidosis due to thyrotoxicosis and massive pulmonary embolism.Case presentation: A 40-year-old man from Cameroun, with history of type 2 diabetes treated with gliclazide and metformin, presented with vomiting and abdominal pain. His vital signs were: blood pressure 140/80 mmHg, heart rate 184 beats per minute and temperature 38.2 °C. On admission, laboratory investigation revealed hyperglycemia, hypero...

Introduction: The causes of arterial hypertension in diabetic and non-diabetic hypertensive patients are still not clear. However, in recent studies in non-diabetic hypertensive patients (NDHP) we observed dysregulation of aldosterone (ALD) secretion either in the form of autonomous secretion or as hyperesponse to stress. To the best of our knowledge, a similar study in hypertensive patients with type 2 Diabetes Mellitus (DHP) has not been conducted yet....

Introduction: Maturity Onset Diabetes of the Young (MODY) constitutes a genetically and clinically heterogeneous type of Monogenic Diabetes (MD). It is characterized by autosomal dominant inheritance, early onset diabetes, defect in the β-cell insulin secretion, positive family history, absence of diabetic ketoacidosis, auto-antibodies and insulin resistance. To date, 14 different MODY subtypes have been reported each one with distinct genetic etiology, however MODY patie...

Aim: Primary goal was to determine whether the improvement of HbA1c, observed in inefficiently insulin-treated diabetes mellitus (DM) patients on a telemonitoring system, had a lasting effect following its discontinuation.Methods: Forty-seven DM patients (mean age 56.15±15.86 years, mean BMI 29.44±6.69 kg/m2, mean HbA1c 9.9±2.62%) and 25 insulin-treated matched controls (mean age 56.16±20.11 years, mean BMI 27.6±5.18 k...

Introduction: Primary aldosteronism (PA) is the most common cause of endocrine hypertension. In recent studies, increased prevalence of hyperparathyroidism (HP) has been observed in PA patients. However, the prevalence of HP in overt or milder forms of PA has not been evaluated yet.Objectives: To estimate the prevalence of HP in patients with PA (overt and milder forms) and investigate the effect of treatment (eplerenone or surgery) on PTH secretion....

Introduction: Insulin autoimmune syndrome (IAS) is characterized by spontaneous hypoglycemia caused by insulin autoantibodies (IA) in the absence of exogenous insulin administration. The occurrence of IAS may be influenced by a genetic predisposition determined by HLA class II. IAS is frequently reported in Japanese and Koreans due to their genetic predisposition (HLA-DRB1*0406) rather than in the Caucasians. Some drugs containing sulfhydryl compounds are known to initiate the...

Background: Adrenal venous sampling (AVS) is the gold standard method that evaluates the source of aldosterone overproduction in primary aldosteronism. During AVS aldosterone and cortisol are simultaneously measured in order to assess successful adrenal cannulation and lateralization of aldosterone overproduction. However, in patients with both adrenal cortisol and aldosterone overproduction, plasma metaneprhines and normetanephrines can be measured to overcome selectivity and...

Introduction’Maturity-onset diabetes of the young’ (MODY) constitutes a group of clinically and genetically heterogeneous monogenic forms of diabetes, characterized by beta-cell dysfunction. It describes an autosomal dominantly inherited disorder, caused by mutations in different genes, characterized by noninsulin-dependent diabetes commonly diagnosed at a young age. Fourteen MODY subtypes have been reported, often misdiagnosed as type 1 or 2 d...

Introduction: Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), formerly known as type II enteropathy-associated T-cell lymphoma, is a rare and aggressive subtype of lymphoma of the gastrointestinal track typically noted in Asian or Hispanic populations. Adrenal involvement as part of MEITL is extremely rare. Herein we present a patient of Greek origin with MEITL and bilateral adrenal metastases.Case Presentation: A 74-year-old man presente...